Over time, this chronic exposure to too much insulin can lead to ‘insulin resistance’ where the body secretes even more insulin in response to the fed state. This leads to a chronic elevation of insulin and a near complete reliance on glucose. 3 As a result, our cells spend less time mobilizing and burning stored body fat, and instead we continuously use the glucose-burning pathways. Unfortunately, we seem to be spending less time in the fasted state and more time in the fed state. The practical importance of all this is that you can burn more stored body fat while in the fasted state, and you store more body fat while in the fed state. 2 The body first burns stored glucose from glycogen, and then starts mobilizing stored body fat from your fat cells and burning it for energy (instead of glucose). In the fasted state, insulin is more likely to be lower (while glucagon and growth hormone, opposing hormones to insulin, are elevated). In the fed state, insulin tend to be elevated, and this signals your body to halt any fat burning, to store excess calories in your fat cells, and burn glucose (from your last meal) instead. You can think of your body as having two different and opposing states: ‘Fed’, and ‘Fasted’. Click for more info.Ī guide by Ted Naiman, MD. This guide is based on scientific evidence, following our policy for evidence-based guides.
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